Title of article
On the design of polymeric 5′-O-ester prodrugs of 3′-azido-2′,3′-dideoxythymidine (AZT)
Author/Authors
Troev، نويسنده , , Kolio D. and Mitova، نويسنده , , Violeta A. and Ivanov، نويسنده , , Ivan G.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
3
From page
6123
To page
6125
Abstract
A new 5′-O-AZT prodrug was synthesized by conjugating 3′-azido-2′,3′-dideoxythymidine (AZT) with poly(oxyethylene H-phosphonate) at room temperature under Atherton-Todd reaction conditions. The acute toxicity of poly(5′-O-AZT-oxyethylene phosphate) was reduced significantly in comparison with non-immobilized AZT.
Keywords
Polymer conjugates , Poly(oxyethylene H-phosphonate)s , TOXICITY , AZT , Anti-HIV prodrugs
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1875562
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