Title of article
Concise, flexible syntheses of 4-(4-imidazolyl)pyrimidine cyclin-dependent kinase 2 (CDK2) inhibitors
Author/Authors
Toumi، نويسنده , , Mathieu and Barbazanges، نويسنده , , Marion and Kroll، نويسنده , , Sebastian H.B. and Patel، نويسنده , , Hetal and Ali، نويسنده , , Simak and Coombes، نويسنده , , R. Charles and Barrett، نويسنده , , Anthony G.M.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
3
From page
6126
To page
6128
Abstract
A flexible six-step synthesis of potential cyclin-dependent kinase 2 (CDK2) inhibitors is reported. The synthesis involves the condensation between 3-chloro-4,4-dimethoxy-2-butanone and amidines, which provides acetyl-imidazoles and late stage palladium-catalyzed N-arylation to give the target pyrimidine derivatives.
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1875568
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