Author/Authors :
Guo، نويسنده , , Jie and He، نويسنده , , Hong-Ping and Fang، نويسنده , , Xin and Di، نويسنده , , Ying-Tong and Li، نويسنده , , Shun-Lin and Zhang، نويسنده , , Zhen and Leng، نويسنده , , Ying and Hua، نويسنده , , Hui-Ming and Hao، نويسنده , , Xiao-Jiang، نويسنده ,
Abstract :
Kansuinone (1), a rearranged euphane triterpenoid containing a spiro [5,6] ring system, was isolated from the roots of Euphorbia kansui. Its structure and stereochemistry were elucidated on the basis of spectroscopic, CD, and computational methods. Kansuinone (1) exhibited inhibitory activity against human and mouse 11β-HSD1 (11β-hydroxysteroid dehydrogenase type 1), with IC50 values of 1.12 and 1.08 μM, respectively.
Keywords :
Euphorbia kansui , Euphane-type triterpene , Structure elucidation , 11?-HSD1 inhibitory activity
