Title of article :
Domino reaction of arylaldehydes and 1-acetylcyclopropanecarboxamides: one-pot access to highly functionalized spiropiperidine-2,4-diones
Author/Authors :
Liu، نويسنده , , Jing and Lin، نويسنده , , Shaoxia and Ding، نويسنده , , Hongqian and Wei، نويسنده , , Ying and Liang، نويسنده , , Fushun، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2010
Abstract :
A domino reaction based on arylaldehydes and 1-acetylcyclopropanecarboxamides has been developed, which allows one-pot and efficient synthesis of structurally complex piperidine-2,4-diones with multiple functionalities under mild conditions. The overall transformation involves tandem aldol/intramolecular aza-Michael/(aldol)/Michael sequences.
Keywords :
Domino reaction , Arylaldehydes , ?-ketoamides , Piperidine-2 , Michael addition , 4-diones
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
