Author/Authors :
Cananzi، نويسنده , , Salvatore and Dallavalle، نويسنده , , Sabrina and Bargiotti، نويسنده , , Alberto and Merlini، نويسنده , , Lucio and Artali، نويسنده , , Roberto and Beretta، نويسنده , , Giovanni Luca، نويسنده ,
Abstract :
In an effort to decrease the toxicity and improve the stability of the E-ring of camptothecin, new analogues with an ‘inverted’ lactone ring were designed and synthesised. The compounds retained a good cytotoxic activity on human non-small lung cancer cells H-460.
Keywords :
Synthesis , camptothecin , molecular docking , Topoisomerase I , antitumour activity
