Title of article :
Radical cation salt induced tandem cyclization between anilines and N-vinyl amides: synthesis of 2-methyl-4-anilino-1,2,3,4-tetrahydroquinoline derivatives
Author/Authors :
Jia، نويسنده , , Xiaodong and Ren، نويسنده , , Yan and Huo، نويسنده , , Cong-de and Wang، نويسنده , , Wenjuan and Chen، نويسنده , , Xiang-Ning and Xu، نويسنده , , Xiaolan and Wang، نويسنده , , Xi-cun، نويسنده ,
Abstract :
A tandem cyclization of imines with N-vinyllactams induced by TBPA+ was investigated, and a series of 2-methyl-4-anilino-1,2,3,4-tetrahydroquinolines were synthesized based on a domino process in which N-vinyllactams serve as an acetaldehyde surrogate. A single electron transfer mechanism was proposed and radical cation salt acts as both a Lewis acid and one electron oxidant to induce such transformation.
