Author/Authors :
Fan، نويسنده , , Junting and Chen، نويسنده , , Yi-Shan and Xu، نويسنده , , Wen-Yan and Du، نويسنده , , Liangcheng and Zeng، نويسنده , , Guang-Zhi and Zhang، نويسنده , , Yumei and Su، نويسنده , , Jia and Li، نويسنده , , Yan and Tan، نويسنده , , Ning-Hua، نويسنده ,
Abstract :
Two novel cyclic hexapeptides, named rubiyunnanins A (1) and B (2), were isolated from the roots of Rubia yunnanensis (Franch.) Diels. Their structures were elucidated extensively by spectroscopic analysis and theoretical computation. Possible biosynthetic pathways for RAs, 1, and 2 were proposed. Compound 2 showed moderate cytotoxicities against 11 cancer cell lines and inhibited nitric oxide (NO) production in LPS and IFN-γ-induced RAW 264.7 murine macrophages.
Keywords :
Rubia yunnanensis , Rubiyunnanin B , cytotoxicity , cyclopeptides , Inhibition of NO production , Rubiyunnanin A
