Synthesis of an epoxyquinol analog: efficient methodology for the insertion of side chains into cyclohexenone cores

A novel epoxyquinol analog was prepared by molecular simplification of monomeric and dimeric scaffolds. A feasible methodology for the insertion of side chains into cyclohexenone skeleton was developed. Insertion of the hydroxymethyl side chain was achieved through α-sulfonylcarbanion chemistry. The alkenyl chain was inserted through palladium cross-coupling strategy.