Title of article
Synthesis and antimalarial activity of new 1,2,4,5-tetroxanes and novel alkoxy-substituted 1,2,4,5-tetroxanes derived from primary gem-dihydroperoxides
Author/Authors
Hamann، نويسنده , , Hans-Jürgen and Hecht، نويسنده , , Mandy and Bunge، نويسنده , , Alexander and Gogol، نويسنده , , Malgorzata and Liebscher، نويسنده , , Jürgen، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
107
To page
111
Abstract
A convenient synthesis of new unsymmetrically substituted 1,2,4,5-tetroxanes and novel unsymmetrical alkoxy-substituted 1,2,4,5-tetroxanes starting from primary dihydroperoxides was developed. The structure of some tetroxanes was unambiguously assigned by X-ray crystal analysis giving interesting insights in the configuration and conformation of disubstituted 1,2,4,5-tetroxanes. Some of these tetroxanes showed notable antimalarial activity in vitro.
Keywords
1 , 2 , 4 , 5-Tetroxanes , orthoesters , Boron trifluoride , antimalarial activity , gem-Dihydroperoxides
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1876302
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