Title of article :
Asymmetric route to spirotetracyclic (1S)-5′,11′-dihydro-3H-spiro[cyclopentane-1,10′-dibenzo[a,d]cyclohepten]-3-one derivatives
Author/Authors :
Gianotti، نويسنده , , Massimo and Andreotti، نويسنده , , Daniele and Casotto، نويسنده , , Davide and Mattioli، نويسنده , , Mario and Mingardi، نويسنده , , Anna and Pavone، نويسنده , , Francesca and Profeta، نويسنده , , Roberto and Valente، نويسنده , , Filippo، نويسنده ,
Abstract :
A new synthetic pathway to the final compound 1-[(1S)-5’,11’-dihydrospiro[cyclopentane-1,10’-dibenzo[a,d]cyclohepten]-3-yl]-3-azetidinecarboxylic acid (1) was set up. The two preparative chiral HPLC separations needed in the first route were successfully avoided and replaced by two diastereomeric crystallizations of intermediate compounds 5 and 10.
Keywords :
Spirotetracyclic compounds , Diazo-insertion , Sleep disorders , Diastereomeric crystallization , Zwitterion
