Title of article
A concise enantioselective synthesis of (+)-goniodiol and (+)-8-methoxygoniodiol via Co-catalyzed HKR of anti-(2SR, 3RS)-3-methoxy-3-phenyl-1, 2-epoxypropane
Author/Authors
Kiran، نويسنده , , I.N. Chaithanya and Reddy، نويسنده , , R. Santhosh and Suryavanshi، نويسنده , , Gurunath and Sudalai، نويسنده , , Arumugam، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
438
To page
440
Abstract
A short, enantioselective synthesis of (+)-goniodiol and (+)-8-methoxygoniodiol, cytotoxic styryllactones, has been achieved in high optical purities (99% ee). The strategy employs Co-catalyzed HKR of racemic anti-(2SR, 3RS)-3-methoxy-3-phenyl-1, 2-epoxypropane and Lewis acid-mediated diastereoselective allylation of aldehyde as chiral inducing key reactions.
Keywords
allylation , diastereoselectivity , styryllactones , Racemic anti-epoxide , Hydrolytic kinetic resolution
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1876545
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