Title of article
Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana
Author/Authors
Hsien، نويسنده , , Chin-Lin and Tseng، نويسنده , , Mei-Hwei and Pan، نويسنده , , Ryh-Nan and Chang، نويسنده , , Jang-Yang and Kuo، نويسنده , , Ching-Chuan and Lee، نويسنده , , Tzong-Huei and Kuo، نويسنده , , Yueh-Hsiung، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
515
To page
517
Abstract
Chemical investigation of the bark of Calocedrus macrolepis var. formosana, an endemic tree in Taiwan, has led to the isolation of a novel terpenoid 1. Compound 1 with a rare C35 skeleton constructed by a diterpene and a sesquiterpene moieties. Its structure was elucidated by spectroscopic interpretations. The anti-proliferation activity of 1 against human oral epidermoid carcinoma KB cells was evaluated, and the IC50 value was determined to be 9.2 ± 0.4 μM.
Keywords
Calocedrus macrolepis , Terpenoid , X-ray crystallography , CUPRESSACEAE
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1876610
Link To Document