Author/Authors :
Massi، نويسنده , , Alessandro and Cavazzini، نويسنده , , Alberto and Zoppo، نويسنده , , Luisa Del and Pandoli، نويسنده , , Omar and Costa، نويسنده , , Valentina and Pasti، نويسنده , , Luisa and Giovannini، نويسنده , , Pier Paolo، نويسنده ,
Abstract :
The activity and stability under flow conditions of covalently and non-covalently silica supported proline and proline-like organocatalysts is herein described. The slow aldol reaction of cyclohexanone with p-nitro benzaldehyde and the fast α-amination of isovaleraldehyde with dibenzyl azodicarboxylate have been selected as model reactions for this study. Prospects and limitations of the disclosed continuous-flow organocatalytic approach are widely discussed.
Keywords :
Continuous-flow processes , Microreactors , organocatalysis , Asymmetric catalysis
