Title of article
‘Click’ to bidentate bis-triazolyl sugar derivatives with promising biological and optical features
Author/Authors
Song، نويسنده , , Zhuo and He، نويسنده , , Xiaopeng Wei Jin Xu، نويسنده , , Xiao-Ping and Gao، نويسنده , , Li-Xin and Sheng، نويسنده , , Li and Zhou، نويسنده , , Yubo and Li، نويسنده , , Jia and Chen، نويسنده , , Guo-Rong، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
894
To page
898
Abstract
Bidentate 1-O-methyl-α-d-pyranoglucosides bearing two triazolyl α-ketoester groups on the 2,6- or 3,4-positions of sugar scaffold were efficiently synthesized via Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (click reaction) in good yields. These newly featured sugar derivatives displayed favorable inhibitory activity on protein tyrosine phosphatase 1B (PTP1B) and unexpected selective fluorescence quenching in the presence of Ni2+.
Keywords
Ni2+ sensor , PTP1B inhibitor , Bidentate O-glucoside , Click reaction , Glycosyl bis-triazole
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1876920
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