Title of article
Reactions of azepinones with electrophiles
Author/Authors
Dubinina، نويسنده , , Galyna G. and Chain، نويسنده , , William J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
939
To page
942
Abstract
Azepinones are available via a one-pot cycloaddition-ring expansion reaction sequence in good yield. The reactions of azepinones with alkyl halides and epoxides were studied. We report herein protocols for the alkylation of azepinones at nitrogen with alkyl halides and epoxides and the isomerizations that occur in the presence of a base. We also report an unexpected ring contraction under oxidative conditions.
Keywords
epoxide , Alkyl halide , Synthesis , Azepinone , Isomerization , ring-expansion , Ring-contraction , Alkylation , alkaloid
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1876958
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