Title of article
Concise syntheses of (±)-protoemetinol and related alkaloids using radical cyclisation
Author/Authors
Palframan، نويسنده , , Matthew J. and Parsons، نويسنده , , Andrew F. and Johnson، نويسنده , , Paul، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
1154
To page
1156
Abstract
Both (±)-protoemetinol, its 3-epi-isomer and (±)-3-desmethyl protoemetinol have been prepared in five linear steps from a dihydroisoquinoline using a 6-exo-trig cyclisation of a vinyl radical in the key step. This novel and particularly short route has potential application in the synthesis of Alangium and Mitragyna alkaloids.
Keywords
tributyltin hydride , radical , Cyclisation , alkaloid
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1877123
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