Concise, regiocontrolled synthesis of yangjinhualine A

The first synthesis of yangjinhualine A, a recently isolated α,β-disubstituted γ-hydroxybutenolide from the Chinese medicinal herb Datura metel L., has been accomplished in concise, entirely regiocontrolled fashion through the combined use of Suzuki–Miyaura cross-coupling and 2-silyloxyfuran oxyfunctionalization.