Title of article
Novel cytotoxic icetexane diterpenes from Premna latifolia Roxb
Author/Authors
Suresh، نويسنده , , G. and Babu، نويسنده , , K. Suresh and Rao، نويسنده , , V. Rama Subba and Rao، نويسنده , , M. Suri Appa and Nayak، نويسنده , , V. Lakshma and Ramakrishna، نويسنده , , Sistla، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
1273
To page
1276
Abstract
Chromatographic fractionation of a hexane extract from stem-bark of Premna latifolia yielded three new icetexane diterpenes (1–3). Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS, data. Compounds 1–3 were also evaluated for the cytotoxicity against the cancer cell lines (HT-29, A-431, MCF-7, Hep-G2, PC-3, A-549, B-16 F10 and ACHN). Compounds 1 and 2 displayed potent cytotoxic activity against HT-29 and Hep-G2 cell lines with IC50 values of 0.04 and 0.18 μg/mL, respectively.
Keywords
Premna latifolia , Icetexane diterpenes , cytotoxic activity , Cancer cell lines
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1877212
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