Title of article
Synthesis of β-fluoro-β-proline
Author/Authors
Yarmolchuk، نويسنده , , Vladimir S. and Mykhailiuk، نويسنده , , Pavel K. and Komarov، نويسنده , , Igor V.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
1300
To page
1302
Abstract
A synthetic strategy towards the novel amino acid β-fluoro-β-proline, a fluorinated analogue of β-proline, is elaborated. The synthesis commences from commercially available methyl 2-fluoroacrylate and involves three steps. The overall yield of β-fluoro-β-proline is 57%.
Keywords
proline , ?-Amino acids , fluorine , Drug Design
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1877234
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