Author/Authors :
Castaٌeda، نويسنده , , Isabel C. Henao and Ulic، نويسنده , , Sonia E. and Védova، نويسنده , , Carlos O. Della and Metzler-Nolte، نويسنده , , Nils and Jios، نويسنده , , Jorge L.، نويسنده ,
Abstract :
We report a simple and suitable method for the preparation of useful 2-trifluoromethylchromones in one step, in high yields and avoiding the use of solvents. We were able to detect the intermediate of this reaction. Furthermore a mechanism for the formation of the 7-methoxy-3-trifluoroacetyl-2-trifluoromethylchromone through the unexpected double trifluoroacetylation of 4-methoxy-2-hydroxyacetophenone followed by dehydration is also proposed. All compounds are fully identified and characterized by spectroscopic techniques.
