Title of article :
Design and synthesis by click triazole formation of paclitaxel mimics with simplified core and side-chain structures
Author/Authors :
Manach، نويسنده , , Claire Le and Baron، نويسنده , , Aurélie and Guillot، نويسنده , , Régis and Vauzeilles، نويسنده , , Boris and Beau، نويسنده , , Jean-Marie، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
A library of paclitaxel (taxol) mimics was obtained by a straightforward strategy involving rational design and an efficient synthesis of a simplified taxane core substitute, together with a click-chemistry combinatorial search for phenylisoserine side-chain surrogates.
Keywords :
l-glucuronolactone , Tubulin depolymerization , click chemistry , Taxoid mimic , Sugar scaffold
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
