Title of article
Design and synthesis by click triazole formation of paclitaxel mimics with simplified core and side-chain structures
Author/Authors
Manach، نويسنده , , Claire Le and Baron، نويسنده , , Aurélie and Guillot، نويسنده , , Régis and Vauzeilles، نويسنده , , Boris and Beau، نويسنده , , Jean-Marie، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
1462
To page
1465
Abstract
A library of paclitaxel (taxol) mimics was obtained by a straightforward strategy involving rational design and an efficient synthesis of a simplified taxane core substitute, together with a click-chemistry combinatorial search for phenylisoserine side-chain surrogates.
Keywords
l-glucuronolactone , Tubulin depolymerization , click chemistry , Taxoid mimic , Sugar scaffold
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1877365
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