Effect of Ga–As (904 nm) and He–Ne (632.8 nm) laser on injury potential of skin full-thickness wound

Injury potential may have a triggering biological role in wound healing. In this study, the effect of photostimulation to promote wound healing and its effect on injury potential was investigated using the Ga–As and He–Ne lasers. In this study, 30 healthy male Sprague–Dawley rats were randomly divided into a control and two laser groups, He–Ne and Ga–As laser. A 2.5 cm craniocaudal full-thickness skin incision was made on each animal’s dorsal region. Differential skin surface potential was measured before and immediately after the injury and also up to the 21st day, every other day. Wound surface area was also measured. Immediately after injury, wound potential significantly increased in all three groups. Maximum positive peak of injury potential was greater in Ga–As group compared to He–Ne laser and control groups (P < 0.05) and lasting period of maximum positive potential in two laser groups was longer than that in the control group. There were no significant differences between the mean potential of before wounding and after the 15th, 17th, and 19th day in Ga–As, He–Ne, and control group, respectively (P > 0.05). On the other hand, Ga–As and He–Ne laser facilitated the normal distribution of skin potential after wounding. findings demonstrate that Ga–As laser may be more effective on wound closure and on returning the injury potential to normal level than the He–Ne laser.