Author/Authors :
Boisse، نويسنده , , Thomas and Gavara، نويسنده , , Laurent and Gautret، نويسنده , , Philippe and Baldeyrou، نويسنده , , Brigitte and Lansiaux، نويسنده , , Amélie and Goossens، نويسنده , , Jean-François and Hénichart، نويسنده , , Jean-Pierre and Rigo، نويسنده , , Benoît، نويسنده ,
Abstract :
The synthesis of thiodeoxyvasicinone and thioluotonin derivatives is described. The results obtained indicate that in these series, oxygen to sulfur replacement leads to absence of strong interaction with topoisomerase I-DNA.
Keywords :
Topoisomerase I , Luotonin , Thioluotonin , camptothecin , Thiocamptothecin , Thiovasicinone , Thiodeoxyvasicinone
