Title of article
Toward new camptothecins. Part 7: Synthesis of thioluotonin and its 5-methoxycarbonyl derivative
Author/Authors
Boisse، نويسنده , , Thomas and Gavara، نويسنده , , Laurent and Gautret، نويسنده , , Philippe and Baldeyrou، نويسنده , , Brigitte and Lansiaux، نويسنده , , Amélie and Goossens، نويسنده , , Jean-François and Hénichart، نويسنده , , Jean-Pierre and Rigo، نويسنده , , Benoît، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
1592
To page
1596
Abstract
The synthesis of thiodeoxyvasicinone and thioluotonin derivatives is described. The results obtained indicate that in these series, oxygen to sulfur replacement leads to absence of strong interaction with topoisomerase I-DNA.
Keywords
Topoisomerase I , Luotonin , Thioluotonin , camptothecin , Thiocamptothecin , Thiovasicinone , Thiodeoxyvasicinone
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1877465
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