Author/Authors :
Wieczorek، نويسنده , , Birgit and Trنff، نويسنده , , Annika and Krumlinde، نويسنده , , Patrik and Dijkstra، نويسنده , , Harm P. and Egmond، نويسنده , , Maarten R. and Koten، نويسنده , , Gerard van and Bنckvall، نويسنده , , Jan-Erling and Gebbink، نويسنده , , Robertus J.M. Klein Gebbink، نويسنده ,
Abstract :
The preparation of a heterogeneous bifunctional catalytic system, combining the catalytic properties of an organometallic catalyst (racemization) with those of an enzyme (enantioselective acylation) is described. A novel ruthenium phosphonate inhibitor was synthesized and covalently anchored to a lipase immobilized on a solid support (CALB, Novozym® 435). The immobilized bifunctional catalytic system showed activity in both racemization of (S)-1-phenylethanol and selective acylation of 1-phenylethanol.
Keywords :
Heterogeneous catalysis , Bifunctional catalytic system , metalloenzyme , DKR , Lipases
