Author/Authors :
Jida، نويسنده , , Mouhamad and Soueidan، نويسنده , , Mohamad and Willand، نويسنده , , Nicolas and Agbossou-Niedercorn، نويسنده , , Francine and Pelinski، نويسنده , , Lydie and Laconde، نويسنده , , Guillaume and Deprez-Poulain، نويسنده , , Rébecca F. Déprez-Poulain، نويسنده , , Benoit، نويسنده ,
Abstract :
A facile and rapid synthetic approach of N-benzyl-2-substituted piperazine building-blocks via an Ugi strategy is described. This strategy is high yielding (80–92% overall yield), step-efficient and fast using microwave heating and tert-butylisocyanide as a convertible isocyanide. This method is useful for the obtention of key intermediates in medicinal chemistry.
Keywords :
multicomponent reaction , microwave , Ugi , Piperazines
