Title of article
A facile and rapid synthesis of N-benzyl-2-substituted piperazines
Author/Authors
Jida، نويسنده , , Mouhamad and Soueidan، نويسنده , , Mohamad and Willand، نويسنده , , Nicolas and Agbossou-Niedercorn، نويسنده , , Francine and Pelinski، نويسنده , , Lydie and Laconde، نويسنده , , Guillaume and Deprez-Poulain، نويسنده , , Rébecca F. Déprez-Poulain، نويسنده , , Benoit، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
1705
To page
1708
Abstract
A facile and rapid synthetic approach of N-benzyl-2-substituted piperazine building-blocks via an Ugi strategy is described. This strategy is high yielding (80–92% overall yield), step-efficient and fast using microwave heating and tert-butylisocyanide as a convertible isocyanide. This method is useful for the obtention of key intermediates in medicinal chemistry.
Keywords
multicomponent reaction , microwave , Ugi , Piperazines
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1877559
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