Title of article :
Total synthesis of topsentolide B2
Author/Authors :
Fernandes، نويسنده , , Rodney A. and Kattanguru، نويسنده , , Pullaiah، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
A stereoselective total synthesis of topsentolide B2, a selective cytotoxic oxylipin against SK-OV-3 and SK-MEL-2 cancer cell lines has been achieved based on asymmetric dihydroxylation, Roush allylation, and ring closing metathesis (RCM) reactions. The synthesis is completed in 11 steps and 2.1% overall yield.
Keywords :
Asymmetric dihydroxylation , Roush allylation , Ring closing metathesis (RCM) , Topsentolides , stereoselective synthesis
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
