Synthesis of a water-soluble triazole-linked cavitand–guanosine conjugate

A convergent synthesis of a water-soluble cavitand bearing four triazole-linked guanosines was achieved. The critical coupling reaction entailed a copper-catalysed azide-alkyne cycloaddition between 5′-azido-5′-deoxyguanosine and a cavitand template functionalized with propargyl ether rim groups and water-solubilizing phosphate pendant groups.