Author/Authors :
Tsaloev، نويسنده , , Alan and Ilyin، نويسنده , , Alexei V. Tkachenko، نويسنده , , Sergey and Ivachtchenko، نويسنده , , Alexandre and Kravchenko، نويسنده , , Dmitry and Krasavin، نويسنده , , Mikhail، نويسنده ,
Abstract :
A method for the chemoselective reduction of Ugi-type lactam amides at the lactam carbonyl functionality with borane complexes has been developed. The novel reduction products can be further manipulated synthetically to yield various novel N- and C-terminally active unnatural amino acid building blocks.
Keywords :
Ugi reaction , chemoselective reduction , unnatural amino acids , Bifunctional reagents
