Title of article :
Asymmetric α-2-tosylvinylation of in situ-generated N-2-tosylvinyl proline-derived ammonium ylides
Author/Authors :
Igarashi، نويسنده , , Tomohito and Tayama، نويسنده , , Eiji and Iwamoto، نويسنده , , Hajime and Hasegawa، نويسنده , , Eietsu، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
Asymmetric α-2-tosylvinylation of N-substituted proline esters using ethynyl tolyl sulfone as an electrophile was shown to proceed in good yield with high enantioselectivities without the addition of any bases. The reaction proceeds via the formation of N-2-tosylvinyl ammonium ylides.
Keywords :
Ylide , asymmetric synthesis , Amino acid , Zwitterion
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
