Title of article
Synthesis of novel ceramide-like penetration enhancers
Author/Authors
Takلcs، نويسنده , , Mلria and Bubenyلk، نويسنده , , Mلté and Vلradi، نويسنده , , Andrلs and Blazics، نويسنده , , Balلzs and Horvلth، نويسنده , , Péter and Kِkِsi، نويسنده , , Jَzsef، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
1863
To page
1865
Abstract
Ceramide-like penetration enhancers have been synthesized by isosteric replacements of the 1-hydroxymethyl and amide moieties of natural ceramides. Metabolically more stable oxime and five-membered heterocyclic (1,2,4-oxadiazole, 1,2,4-triazole, tetrazole) analogues are more polar and possess H-bond acceptor properties, which make them potentially useful in optimizing key intermolecular features in interactions between the modified ceramide structures and the lipid layers of stratum corneum.
Keywords
Ceramide , Isostere replacement , Penetration enhancer , Oxime
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1877661
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