Title of article
A mild, large-scale synthesis of 1,3-cyclooctanedione: expanding access to difluorinated cyclooctyne for copper-free click chemistry
Author/Authors
Sims، نويسنده , , Evan A. and DeForest، نويسنده , , Cole A. and Anseth، نويسنده , , Kristi S.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
1871
To page
1873
Abstract
We report the large-scale synthesis of 1,3-cyclooctanedione in five steps with 29% yield. This molecule is a synthetic precursor to difluorinated cyclooctyne, which participates in a bioorthogonal copper-free click reaction with azides. The final step demonstrates the first successful application of the Wacker–Tsuji oxidation to form a cyclic 1,3-dione.
Keywords
Wacker–Tsuji oxidation , Cyclooctanedione , Difluorinated cyclooctyne , Copper-free click chemistry
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1877666
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