Title of article
Copper-catalyzed oxidative trifluoromethylation of benzylic sp3 C–H bond adjacent to nitrogen in amines
Author/Authors
Mitsudera، نويسنده , , Hiromasa and Li، نويسنده , , Chao-Jun، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
1898
To page
1900
Abstract
Copper-catalyzed trifluoromethylation via oxidative sp3 C–H activation at the α-position of nitrogen in tetrahydroisoquinoline derivatives using DDQ and Ruppert–Prakash reagent has been successfully achieved. The reaction of various amines gave the corresponding trifluoromethylated products in 15–90% yields under mild conditions.
Keywords
C–H functionalization , Copper-catalyzed , fluorination , oxidative coupling , heterocycle
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1877687
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