Title of article
Cross-couplings of alkyl halides with heteroaromatic halides, in water at room temperature
Author/Authors
Krasovskiy، نويسنده , , Arkady and Thomé، نويسنده , , Isabelle and Graff، نويسنده , , Julien and Krasovskaya، نويسنده , , Valeria and Konopelski، نويسنده , , Paul and Duplais، نويسنده , , Christophe and Lipshutz، نويسنده , , Bruce H.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
2203
To page
2205
Abstract
Zn-mediated, Pd-catalyzed cross-coupling reactions between heteroaromatic and alkyl halides can be done at room temperature in pure water using a commercially available Pd catalyst and PTS, a nanomicelle-forming amphiphile. Notably, zinc metal inserts selectively into a carbon sp3-halide bond, while palladium adds oxidatively to a carbon sp2-bond.
Keywords
Negishi-like cross-coupling , Pd catalysis , micellar catalysis , Heteroaromatic halides , green chemistry
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1877882
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