Title of article
A concise approach towards the synthesis of WS75624 A and WS75624 B via the cross-metathesis of vinyl-functionalized thiazoles
Author/Authors
Dash، نويسنده , , Jyotirmayee and Melillo، نويسنده , , Bruno and Arseniyadis، نويسنده , , Stellios and Cossy، نويسنده , , Janine، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
2246
To page
2249
Abstract
Synthetic approach towards precursors of WS75624 A and WS75624 B, two potent endothelin converting enzyme (ECE) inhibitors and potential antihypertensive agents, is reported featuring a key cross-metathesis between a vinyl-functionalized thiazole and a terminal olefin. As the two natural products only differ by the nature of their hydroxyalkyl side-chain, our convergent strategy enable the synthesis of key intermediates of both molecules in a limited amount of steps.
Keywords
cross-metathesis , natural products , Alkene , Thiazole , pyridine
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1877916
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