Title of article
Syntheses and biological evaluation of new triazole-spirochromone conjugates as inhibitors of Mycobacterium tuberculosis
Author/Authors
Muthukrishnan، نويسنده , , M. and Mujahid، نويسنده , , M. and Yogeeswari، نويسنده , , P. and Sriram، نويسنده , , D.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
2387
To page
2389
Abstract
A series of novel 1,2,3-triazole fused spirochromone conjugates have been synthesized bearing both spirochromone moiety as well as a 1,2,3-triazole moiety. Some of the compounds have exhibited potential activity against Mycobacterium tuberculosis (virulent strain H37Rv). In particular 5e proved to be the most potent derivative exhibiting MIC = 0.78 μg/mL.
Keywords
Spirochromones , antitubercular activity , Mycobacterium tuberculosis , click chemistry
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878010
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