Title of article
Regioselective deuteration of 25,27-dialkoxycalix[4]arenes
Author/Authors
Ma?kov?، نويسنده , , Michaela and Himl، نويسنده , , Michal and Min??ov?، نويسنده , , Lenka and Lang، نويسنده , , Jan and Lhot?k، نويسنده , , Pavel، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
2543
To page
2546
Abstract
A direct deuteration of the upper rim of calix[4]arene has been carried out for the first time. 25,27-Dialkoxy derivatives of calix[4]arene (R = Me, Et, n-Pr, n-Bu) were regioselectively deuterated at the para positions of unsubstituted phenolic rings using DCl/D2O in tetrachloroethane. Interestingly, identical reaction conditions do not lead to deuteration of mono- or tri-substituted derivatives where only simple cleavage of alkyl substituents was observed.
Keywords
Calixarenes , Deuteration , Regioselective substitution , hydrogen–deuterium exchange
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878132
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