Title of article
Dihydrohymenialdisines, new pyrrole-2-aminoimidazole alkaloids from the marine sponge Cymbastela cantharella
Author/Authors
Sauleau، نويسنده , , Pierre and Retailleau، نويسنده , , Pascal and Nogues، نويسنده , , Stéphanie and Carletti، نويسنده , , Isabelle and Marcourt، نويسنده , , Laurence and Raux، نويسنده , , Roselyne and Mourabit، نويسنده , , Ali Al and Debitus، نويسنده , , Cécile، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
2676
To page
2678
Abstract
In our investigation of bioactive marine natural products, we revisited an ethanolic extract of the New Caledonian sponge Cymbastela cantharella. Four new natural compounds (3–6) were isolated and their structural determinations as dihydrohymenialdisine derivatives were achieved by spectral data analysis and chemical conversion. These products did not show any activity in the Polo Like kinase bioassay, demonstrating thus the importance of the unique structure of hymenialdisine, known as an improved kinase inhibitor.
Keywords
Marine sponge , Dihydrohymenialdisine , Pyrrole-2 aminoimidazole , Cymbastela cantharella
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878240
Link To Document