Low-level laser therapy (LLLT) (660 nm) alters gene expression during muscle healing in rats

Introduction fects of LLLT were studied during muscle regeneration through gene expression. s evaluated 10 and 50 J/cm2 doses during 7, 14 and 21 days post cryoinjury, through histopathological analysis and mRNA MyoD, Myogenin, Vegf and Cox-2 expression. s ated groups presented less inflammatory process than control group after 14 and 21 days. Cox-2 levels were downregulated in all irradiated groups after 7, 14 and 21 days. On day 7, both treated groups had a downregulation of Vegf levels, and an upregulation after 14 and 21 days, mainly with 50 J/cm2. The MyoD levels were upregulated with high dose in all periods and with low dose after 21 days. Myogenin expression was downregulated in both treated groups after 7 days, and was upregulated with 10 J/cm2 after 21 days. sion responses suggest that LLLT can improve the skeletal muscle regeneration through the gene expression stimulation.