Microwave-assisted methylation of phenols with DMF-DMA

We evaluated the potential of N,N-dimethylformamide dimethylacetal (DMF-DMA) as a methylating agent for a library of para-substituted phenols under microwave irradiation. The rate of reaction was dictated by the electronic nature of the para-substituent. With an electron-withdrawing group the reaction was completed within 30 min. For electron-donating groups, the reaction times were 60 min. Esterification and enamino-ketone formation was also observed with carboxylic acid and ketone functional groups, respectively.