Title of article :
Oxidation of caffeine with hydrogen peroxide catalyzed by metalloporphyrins
Author/Authors :
Neves، نويسنده , , Clلudia M.B. and Simُes، نويسنده , , Mلrio M.Q. and Santos، نويسنده , , Isabel C.M.S. and Domingues، نويسنده , , Fernando M.J. and Neves، نويسنده , , M. Graça P.M.S. and Almeida Paz، نويسنده , , Filipe A. and Silva، نويسنده , , Artur M.S. and Cavaleiro، نويسنده , , José A.S.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
The biomimetic oxidation of caffeine with hydrogen peroxide using metalloporphyrins as catalysts, which are known to be good biomimetic models of cytochrome P450 enzymes, is investigated. The two manganese porphyrins tested, chloro[5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrinato]manganese(III), [Mn(TDCPP)Cl], and chloro [5,10,15,20-tetrakis(pentafluorophenyl)porphyrinato]manganese(III), [Mn(TPFPP)Cl], afford high conversions of caffeine for all substrate/catalyst molar ratios. Selectivity was found to be dependent on the catalyst employed, and a new spiro racemic compound is described and fully characterized in the solid state from X-ray diffraction studies.
Keywords :
Biomimetic oxidation , Hydrogen peroxide , Manganese porphyrins , caffeine
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
