Title of article
Oxidation of caffeine with hydrogen peroxide catalyzed by metalloporphyrins
Author/Authors
Neves، نويسنده , , Clلudia M.B. and Simُes، نويسنده , , Mلrio M.Q. and Santos، نويسنده , , Isabel C.M.S. and Domingues، نويسنده , , Fernando M.J. and Neves، نويسنده , , M. Graça P.M.S. and Almeida Paz، نويسنده , , Filipe A. and Silva، نويسنده , , Artur M.S. and Cavaleiro، نويسنده , , José A.S.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
2898
To page
2902
Abstract
The biomimetic oxidation of caffeine with hydrogen peroxide using metalloporphyrins as catalysts, which are known to be good biomimetic models of cytochrome P450 enzymes, is investigated. The two manganese porphyrins tested, chloro[5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrinato]manganese(III), [Mn(TDCPP)Cl], and chloro [5,10,15,20-tetrakis(pentafluorophenyl)porphyrinato]manganese(III), [Mn(TPFPP)Cl], afford high conversions of caffeine for all substrate/catalyst molar ratios. Selectivity was found to be dependent on the catalyst employed, and a new spiro racemic compound is described and fully characterized in the solid state from X-ray diffraction studies.
Keywords
Biomimetic oxidation , Hydrogen peroxide , Manganese porphyrins , caffeine
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878402
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