Title of article
Baylis–Hillman-derived N,N′-disubstituted piperazines: structural and preliminary computational studies
Author/Authors
D. O. Idahosa، نويسنده , , Kenudi C. and Lee، نويسنده , , Yi-Chen and Nyoni، نويسنده , , Dubekile and Kaye، نويسنده , , Perry T. and Caira، نويسنده , , Mino R.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
2972
To page
2976
Abstract
Exploratory studies towards the preparation of potential HIV-1 protease and integrase inhibitors have led to the synthesis of Baylis–Hillman-derived N,N′-disubstituted piperazines. X-ray crystallographic, computer modelling and NMR techniques have been used to elucidate questions concerning configurational preferences, reaction pathways and the apparent difference in susceptibility towards aza-Michael reactions exhibited by methyl acrylate and methyl vinyl ketone (MVK) derived Baylis–Hillman substrates.
Keywords
Computational Studies , Diffusion-ordered spectroscopy (DOSY) , Piperazines , 2D NOE (NOESY) , Aza-Michael , X-ray crystallography , Baylis–Hillman
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878437
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