Title of article :
Copper-free defluorinative alkylation of allylic difluorides through Lewis acid-mediated C–F bond activation
Author/Authors :
Yanai، نويسنده , , Hikaru and Okada، نويسنده , , Haruna and Sato، نويسنده , , Azusa and Okada، نويسنده , , Midori and Taguchi، نويسنده , , Takeo، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
The reactions of difluorohomoallyl alcohols with trialkylaluminiums smoothly proceeded in CH2Cl2 at room temperature to give (Z)-fluoro-olefin products in excellent yields. On the basis of this chemistry, fluoro-olefinic dipeptide isostere of norvalinyl glycine was synthesized in stereoselective manner.
Keywords :
C–F bond cleavage , Organoaluminium , Peptide isostere , Lewis acid , Fluoroalkene
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
