Title of article
A novel approach for the one-pot synthesis of linear and angular fused quinazolinones
Author/Authors
Maity، نويسنده , , Arindam and Mondal، نويسنده , , Shyamal and Paira، نويسنده , , Rupankar and Hazra، نويسنده , , Abhijit and Naskar، نويسنده , , Subhendu and Sahu، نويسنده , , Krishnendu B. and Saha، نويسنده , , Pritam and Banerjee، نويسنده , , Sukdeb and Mondal، نويسنده , , Nirup B.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
3033
To page
3037
Abstract
A convenient and inexpensive one step methodology has been developed for the synthesis of linear and angular fused quinazolinones. The protocol, which uses amino heterocycles and o-bromo benzyl/naphthyl bromides as reactants, CuI as catalyst, Cs2CO3 as base, l-proline as ligand, and DMF as solvent, proceeds via nucleophilic aromatic substitution of the N-heteroaromatic cationic intermediate followed by in situ aerial oxidation at the benzylic position to the quinazolinone scaffold.
Keywords
CuI , Cs2CO3 , Linear and angular annulated quinazolinones , L-proline
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878464
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