Title of article
Synthesis and characterization of photoaffinity probe of acetogenin, a strong inhibitor of mitochondrial complex I
Author/Authors
Yamamoto، نويسنده , , Shuhei and Abe، نويسنده , , Masato and Nakanishi، نويسنده , , Sayo and Murai، نويسنده , , Masatoshi and Miyoshi، نويسنده , , Hideto، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
3090
To page
3093
Abstract
Acetogenins are valuable inhibitor probes to get an insight into the structural and functional properties of mitochondrial NADH-ubiquinone oxidoreductase (complex I). We synthesized a photoreactive acetogenin mimic ([125I]DANA) which retained a strong inhibitory activity. The preliminary photoaffinity labeling with bovine heart submitochondrial particles revealed that [125I]DANA binds to the ND1 subunit among 45 different subunits with high specificity.
Keywords
Acetogenins , Photoaffinity labeling , Mitochondrial complex I , Respiratory enzyme , Radioiodination
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878490
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