Title of article
Highly efficient and enantioselective Michael addition of acetylacetone to nitroolefins catalyzed by chiral bifunctional organocatalyst bearing multiple hydrogen-bonding donors
Author/Authors
Shi، نويسنده , , Xin and He، نويسنده , , Wei and Li، نويسنده , , Hua and Zhang، نويسنده , , Xu and Zhang، نويسنده , , Shengyong، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
3204
To page
3207
Abstract
A new efficient catalyst system for the asymmetric addition of acetylacetone to nitroolefins using a chiral bifunctional organocatalyst bearing multiple hydrogen-bonding donors was developed. When using the organocatalyst 2c derived from natural cinchona alkaloid in optimal conditions, up to 98% chemical yield and 98% ee were observed with a variety of aromatic nitroolefins.
Keywords
Michael addition , Cinchona alkaloids , bifunctional organocatalyst , Hydrogen-bonding donor
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878540
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