Chiral Pd-catalyzed enantioselective Friedel–Crafts reaction of indoles with γ,δ-unsaturated β-keto phosphonates

The catalytic enantioselective Friedel–Crafts alkylation reaction promoted by chiral palladium complexes is described. The treatment of indoles with γ,δ-unsaturated β-keto phosphonates under the mild reaction conditions afforded the corresponding Friedel–Crafts alkylation adducts with excellent enantioselectivities (up to 99% ee).