Title of article :
A highly regioselective hydroformylation of an α-chiral olefin to produce a versatile trifunctionalised orthogonally protected C5 synthon
Author/Authors :
Cobley، نويسنده , , Christopher B. Meek، نويسنده , , Graham K. Rand، نويسنده , , Cynthia، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Pages :
4
From page :
3271
To page :
3274
Abstract :
This paper describes a highly regioselective hydroformylation of (R)-N-phthalimido-vinylglycinol, [(R)-PVG]. By judicious choice of the reaction conditions, catalyst-controlled preferential formation of the linear regioisomer could be achieved in excellent yield. The hydroformylation product cyclised to a hemi-acetal, which is an orthogonally protected trifunctionalised enantio-enriched C5 synthon. The value of this versatile intermediate was demonstrated by the ready formation of enantio-enriched amino-diols, diamino-alcohols and differentially protected (R)-3-aminopiperidine.
Keywords :
Trifunctionalised synthon , Regioselective hydroformylation
Journal title :
Tetrahedron Letters
Serial Year :
2011
Journal title :
Tetrahedron Letters
Record number :
1878573
Link To Document :
بازگشت