Author/Authors :
Tang، نويسنده , , Changhua and Li، نويسنده , , Ziyuan and Wang، نويسنده , , Yiyun and Xu، نويسنده , , Jinyi and Kong، نويسنده , , Lingyi and Yao، نويسنده , , Hequan and Wu، نويسنده , , Xiaoming، نويسنده ,
Abstract :
The first total synthesis of a sesquiterpenoid, tenuifolin, was achieved in seven linear steps. Phenyliodine(III) bis(trifluoacetate) (PIFA) mediated oxidative biaryl coupling was employed as a key step to construct the central seven-membered ring with a double bond. The double bond formation was also exploited.
Keywords :
antitumor , Oxidative biaryl coupling , total synthesis , Tenuifolin , Wittig coupling
