Title of article
Robust routes for the synthesis of N-acylated-l-homoserine lactone (AHL) quorum sensing molecules with high levels of enantiomeric purity
Author/Authors
Hodgkinson، نويسنده , , James T. and Galloway، نويسنده , , Warren R.J.D. and Casoli، نويسنده , , Mariangela and Keane، نويسنده , , Harriet and Su، نويسنده , , Xianbin and Salmond، نويسنده , , George P.C. and Welch، نويسنده , , Martin and Spring، نويسنده , , David R.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
3291
To page
3294
Abstract
The ready availability of native quorum sensing molecules and related structural analogues is of significant biological interest in the development of methods to manipulate bacterial quorum sensing systems in a useful fashion. In this Letter we report robust routes for the synthesis of a range of N-acylated-l-homoserine lactone (AHL) quorum sensing molecules. Crucially, we have analysed the enantiopurity of the final AHLs and in all cases, excellent levels were observed.
Keywords
Synthesis , Enantiomeric purity , Pseudomonas aeruginosa , N-acylated-l-homoserine lactones (AHLs) , quorum sensing
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878581
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