Title of article
Clausenawallines A and B, two new dimeric carbazole alkaloids from the roots of Clausena wallichii
Author/Authors
Maneerat، نويسنده , , Wisanu and Ritthiwigrom، نويسنده , , Thunwadee and Cheenpracha، نويسنده , , Sarot and Prawat، نويسنده , , Uma and Laphookhieo، نويسنده , , Surat، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
3303
To page
3305
Abstract
Two new dimeric carbazole alkaloids, clausenawallines A and B, were isolated from the roots of Clausena wallichii. Their structures were elucidated by spectroscopic methods. Clausenawalline A was evaluated for its biological activities [anti-malaria (IC50 2.46 μg/mL), anti-TB (MIC 12.50 μg/mL)] and cytotoxicity against three human cancer cell lines [KB (IC50 7.87 μg/mL), MCF7 (IC50 25.43 μg/mL), and NCI-H187 (IC50 10.97 μg/mL)].
Keywords
Clausena wallichii , Carbazole alkaloid , Clausenawalline A , Clausenawalline B , Anti-malaria , Anti-TB , cytotoxicity
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878586
Link To Document